SEURAT Visualizations

Now includes direct integration with SpotFile™

Free Built-In Visualization

SEURAT has its own SpotFire™-like visualization capabilities that can be launched from the Assay Display. The state of the visualizations suite can then be saved at anytime (we call this a visualization snapshot) and those saved snapshots can then be reapplied the next time you run your SEURAT job against newly arrived data.

This is a powerful capability that allows you to build up a set of visual models which test a hypothesis or call out a trend or correlation in the data and then constantly re-test those models against the latest data as it arrives.

Scatter Plot A simple scatter plot of cMet assay results broken down by scaffold and color coded by selectivity

The main visualization in SEURAT is an initial scatter plot from which any number of other visualizations (more scatter plots, heat maps, box plots, matrices of box plots etc) can be added to the set of visualizations being shown.

All such visualizations are linked for selection, dynamic filtering and visual options of color, size, label and sort order meaning that a change in one visualizations through the control panel is reflected in all other visualizations simultaneously.

	Control Panel - Filters All visualizations are simultaneously dynamically filtered when the sliders are moved. Ki values are automatically log scaled
	Control Panel - Visual All visualizations simultaneously reflect the selections in the visual panel giving six dimensions of data through color, size, label, sort order, X and Y axes

	Heat Map SEURAT heat map where both columns and rows can be dragged and dropped to bring the hot spots together. Then the zoom control used to inspect what it is about the structure of those compounds that infers across drug likeness in the majority of compound properties
	Box Plot SEURAT box plots can be used to compare the spread of data for a given property between scaffolds for example.

Kinase Space Visualizations

In addition to the standard visualizations described above that can be applied to any result set SEURAT also provides two views specifically into Kinase space.

The Human Kinome Tree Viewer can be used to determine at a glance the selectivity of your compounds in Kinase space and to compare your compounds selectivity to that of known Kinase based drugs.

Human Kinome Tree Viewer Comparing the selectivity of CRA-03360 (red dots) to that of Gleevec (pink dots)

Once selectivity is visualized at a high level as shown particular areas of interest can be selected and zoomed into to determine which Kinase the activity is against. Switching to the Assay Data tab shows the underlying numeric values used to derive the visual.

The size of the plotted dots is directly proportional to the potency of the activity against that Kinase. Boxes are drawn for activity against mutated forms.

GVK Browser

Provides a tractable user interface to browse and structure search the Kinaes database of data gleaned from all publications relating to kinase space from GVK bio. See www.gvkbio.com for more details about the kinase database they provide.

The SEURAT GVK browser makes the data in the database accessible to all users.

GVK Browser How to launch, search both text based and structure based and then browse the results of the GVK Browser visualization

Of course as this is a proprietary database it is not shipped by default with SEURAT. If you company is interested in using the GVK Kinase Browser which implies purchasing a license to the database from GVK then please contact us at sales@synapticscience.com